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Company:
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Interlab Srl
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Summary: |
The Microgel/Interlab G26 Acid Hemoglobins Electrophoresis method provides a new level of total automation on agarose gel.
You simply pipette the hemolysates into the sample wells, put the gels in the holders, start the instrument and walk away!
Synthesis of hemoglobin is under genetic control and the presence of abnormal hemoglobins is associated with functional, physical and morphological abnormalities of the red cells.
Hemoglobins are composed of polypeptide chains of globin and iron protoporphyrin heme groups.
Normal hemoglobins have similar structures with a molecular weight of about 67,000 daltons and consist of 2 pairs of globin chains each associated with one molecule of heme.
Normal adult hemoglobins are HbA (98 percentage of total hemoglobin) and small amounts of HbA2 and HbF. Substitution of aminoacids in the polypeptide chains sequence leads to the formation of abnormal hemoglobin variants. At present over 600 structural hemoglobins variants are known: HbS, HbC, HbE, HbD, HbG, HbH, HbI, Hb Lepore, etc. Hemoglobinopathies are a group of diseases caused by the presence of abnormal hemoglobins.
About 60 percentage of abnormal hemoglobins have a sufficiently altered charge distribution to be identified by electrophoresis. The variants most frequently observed are HbS and HbC.
Concomitant presence of HbA and another variant (HbS, HbC, HbE, etc.) is referred to as heterozygous hemoglobinopathy AS, AC and AE respectively. The presence of only one single type of hemoglobin variant is called homozygous hemoglobinopathy, like HbS or HbC.
These abnormal variants are genetically transmissible. Homozygous hemoglobinopathies may cause serious clinical effects. Acid hemoglobin electrophoresis on agarose allows confirmation of the presence of HbS or HbC already detected by Alkaline Hemoglobins electrophoresis.
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Resource: |
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