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Synthesis of hemoglobin is under genetic control and the presence of abnormal hemoglobins is associated with functional, physical and morphological abnormalities of the red cells.
Hemoglobins are composed of polypeptide chains of globin and iron protoporphyrin heme groups.
Normal hemoglobins have similar structures with a molecular weight of about 67,000 daltons and consist of 2 pairs of globin chains each associated with one molecule of heme.
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