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Diagnostic Automation, Inc.
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In recent years it has become clear that autoantibodies to a number of nuclear constituents have proven to be useful in the diagnosis of various connective tissue diseases. The Jo-1 autoantibody is one of a family of characteristic autoantibodies seen in myositis patients (19). They are all specifically found in patients withmyositis, and are all associated with a high incidence of accompanying interstitial lung disease (10). Antibodies directed against the Sm marker are highlyspecific for patients with SLE and are considered a diagnostic criterion for SLE (1,2). The presence of high level RNP
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