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Diagnostic Automation, Inc.
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Systematic autoimmune disease is characterized by the presence of circulating autoantibodies directed to a wide variety of cellular antigens (1,2,3). Systemic lupus erythematosis (SLE), commonly referred to as Lupus, is the best known of these diseases. Other possible connective
tissue diseases include mixed connective tissue disease (MCTD), Sjogren syndrome, sclerodema, and polymyositis/dermatomyositis. The majority can be diagnosed by clinical presentation and their antibody profiles to the various antigens involved, which include dsDNA, Sm, RNP, Ro, La, Scl-70, Jo-1, and Histones.Therefore,
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