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Proteins form the major portion of the solutes dissolved in the plasma
fluid. Total protein determinations are useful in detecting
hyperproteinemia due to homoconcentration as occurred in
dehydration, paraproteinemia, or monoclonal disease (multiple
myeloma, macroglobulinemia, cryoglobuliemia) and in some chronic
polyclonal diseases, liver cirrhosis, sarcoidosis, systemic lupus
erythematosus, and chronic infections.
Conditions which result in serum protein decrease involving
overhydration, protein loss through kidneys, severe burns, or in failure
of protein synthesis (starvation, protein malnu
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