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Creatine kinases are dimeric molecules composed of M and B subunits
and exist as the isoenzymes MM, MB, and BB.1 The subunits M and B
are immunologically distinct; CK-MM and CK-MB are distributed
primarily in the skeletal muscle and heart muscle, respectively. While
CK-BB is present mainly in the brain and in tissues composed of smooth
muscle.2 Following acute myocardial infarction, CK-MB activity
increases significantly and this elevation is highly specific for the
laboratory diagnosis of myocardial infarction.3,4 Although total CK
activity usually increases following myocardial infarction, i
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