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Creatine Kinase (CK) plays an important role in the energy-storing
mechanism of tissue by catalyzing the reversible reaction between
creatine and ATP to form creatine phosphate and ADP. CK is
distributed in various organs; the highest activities (in decreasing
order) are skeletal muscle, heart, and brain.1 Thus, determination of
CK is an aid in diagnosing muscular dystrophy and other diseases of
the skeletal muscles, myocardial infarction, hypothyroidism, renal
diseases, and/or dysfunction.2
The early procedure for determining CK was based on the rate of
ATP formation.3 A modified method was d
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