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Diagnostic Automation, Inc.
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Diagnostic Automation 17-Hydroxyprogesterone (17-OH progesterone or 17OHP) is a C-21 steroid hormone
produced in the adrenal gland and gonads, during the synthesis of glucocorticoids and sex steroids. It is derived
from progesterone via 17-hydroxylase, a P450c17 enzyme, or from 17-hydroxypregnenolone via 3β-hydroxysteroid
dehydrogenase/Δ5-4 isomerase.
17α -OHP has no defined physiologic role except as a precursor molecule.
Serum 17α -OHP levels are age-dependent, with peak levels observed during fetal life and the immediate postnatal
period. During the first week of life, serum 17α -OHP level
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