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More than 99 of body calcium exists in bones and teeth. The
remaining 1 is present in blood and soft tissues and serves as a cofactor
in blood coagulation, metabolism, and neuromuscular physiology.
Serum calcium is present in three different forms: 1) nearly 45 is
bound by serum proteins, 2) about 5 is complexed in a non-ionized
form and 3) the remaining 50 serum calcium is in an ionic (free) form.
It is the physiologically active ionic fraction that is important in terms of
biological function.
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